TTP Labtech Workshop: Accelerating, Miniaturised Assay Development and Mechanistic Biology – Exploring a Collaborative Approach to Reduce Early Drug Discovery Cycle Times
Wednesday, 27 June | 10:30 – 11:30 | Studio 311
Speaker: Daniel A. Thomas, Ph.D. GSK
The complexities of assay development and challenges associated with validating and transferring assays into HTS are well-known bottlenecks in the drug discovery process. Industry experts from GSK and TTP Labtech will discuss how they have collaborated in order to address this with the application of a novel liquid handling technology, which can be utilised for both complex, multifactorial assay development experiments as well as large scale, high throughput, drug discovery screening. dragonfly discovery has enabled researchers at GSK to significantly reduce assay development costs and cycle times, through the application of automated design of experiment (DoE), which has led to an improvement in reproducibility and a subsequent increase in assay quality.
Efficient and High-Throughput Mining of the B Cell Repertoire to Discover Antibodies with Desirable Characteristics
Speaker: Ruth McElhone, Antibody Discovery Scientist, UCB
- UCB’s Core antibody discovery platform is used to find high quality functional monoclonal antibodies to a range of therapeutic targets, including those that are considered extremely challenging.
- It combines high-throughput B cell culture screening, and the identification and isolation of single, antigen specific IgG-secreting B cells through a proprietary technique called the ‘fluorescent foci method’.
- We utilise the TTP Labtech Mirrorball® device to perform multiplex primary binding assays enabling us to define antibody specificity early in the screening cascade.
- Our Core platform also enables the discovery of antibodies to challenging cell surface targets, where immunisation, screening and single B cell isolation are all performed in the absence of purified protein.
Perkin Elmer Workshop: A Microfluidics Workflow for Sample Preparation for Next-Generation DNA Sequencing
Wednesday, 27 June | 10:30 – 11:30 | Studio 316
NGS library prep is plagued by sample loss, long protocol times, many manual steps and high cost. In this new workflow, each library preparation step is optimized using microfluidic two-phase channels with magnetic bead motion. The resulting workflow offers efficient and low-cost preparation of NGS libraries from low cell count and low volume samples.
Corning Workshop : Rock the Science of 3D: From Promise to Reality
Wednesday, 27 June | 12:45 – 13:45 | Studio 312
Richard M. Eglen, Ph.D.
Vice President and General Manager
Corning Incorporated l Life Sciences
3D cell culture is exploding. Life-like models that have never before been possible are becoming a reality in the hands of innovative scientists around the world. Hear Richard Eglen, Corning Life Sciences Vice President and General Manager, review some of the most ground-breaking research in the space and discuss the exciting promise of 3D in the future as it relates to drug screening.
Abcam Workshop: Introducing FirePlex®-HT: A new high throughput, multiplex immunoassay using FirePlex Particle technology
Wednesday, 27 June | 12:45 – 13:45 | Studio 314
In this seminar, we will highlight the unique features of the FirePlex’s particle-based multiplexing, and present the FirePlex miRNA and Immunoassays which can be customized for a broad range of research areas, including organ injury, inflammation, and cancer immunology. We will also introduce the new FirePlex-HT, a two-step, no-wash immunoassay specifically designed for high-throughput biomarker screening studies.
Thursday, 28 June
Promega Workshop: Monitoring Protein Dynamics at Endogenous Levels with a Luminescent Peptide Tag
Thursday, 28 June | 8:30 – 10:00 | Studio 311
Speaker: Christopher T. Eggers, Ph.D., Senior Research Scientist from Promega’s R&D team in Madison, WI (USA)
Dr. Eggers will present on a new technology from Promega (called HiBiT) which is used to study protein dynamics in the cellular environment. The HiBiT Protein Tagging System enables the simple and sensitive quantification of intracellular or extracellular proteins at endogenous levels. High-affinity complementation of the 11-amino-acid HiBiT peptide with the 18 kDa LgBiT subunit generates the bright, luminescent NanoBiT® enzyme. The small size and sensitivity of HiBiT make it an ideal tag for measuring the dynamics of endogenously expressed proteins. Tagging of proteins with HiBiT can be accomplished either through traditional cloning techniques or by CRISPR/Cas9 gene editing using a rapid cloning-free protocol. The HiBiT tag can be detected in multiple HTS-compatible assay formats to measure: i) Changes in protein expression, stabilisation and degradation (including proteolysis targeting chimeric molecules – PROTACs), ii) Receptor internalisation, iii) Protein trafficking and iv) Protein secretion. The presentation will be followed by a question and answer session.
Hamamatsu Photonics Workshop: High Throughput Screening for Drug Development and Safety Assessment using Human iPSC-derived Cells
Thursday, 28 June | 8:30 – 10:00 | Studio 312
Labcyte Workshop: The New Sound of Sample Management – High-Throughput, Fully-Automated, Production of Assay-Ready Plates from Samples Stored in Tubes using Echo® Acoustic Liquid Handling on the New Access™ Dual-Robot System for Acoustic Sample Management.
Thursday, 28 June | 8:30 – 10:00 | Studio 314
Stuart Ratcliffe – Senior Scientist – Compound Management, AstraZeneca, Alderley Park, UK
Iain Russell, Ph.D. – Senior Product Manager – Echo Liquid Handler Product Line, Labcyte, San Jose, CA
Justin Jager – Product Manager – Lab Automation, Labcyte, San Jose, CA
Toby Winchester – Automation Product Manager, Titian Software, London, UK
Genedata, HighRes Biosolutions, Titian Software Workshop: Partnering to Close the Screening Loop: from Sample Logistics to Automation to Analysis and Back
Thursday, 28 June | 13:15 – 14:15 | Studio 311
- Oliver Leven, Head of Screener Business Europe, Genedata
- Jack Dawson, Director of Applications, HighRes Biosolutions
- Toby Winchester, Automation Product Manager, Titan Software
The drug discovery research process consists of iterations between designing and planning, testing, and analyzing. HighRes Biosolutions, Titian, and Genedata together present an integrated set of products to support this iterative lifecycle. The approach offers a seamless workflow from sample logistics to automation to analysis and back, effortlessly moving information to where it needs to be and ultimately providing researchers with the time and freedom to focus on their science.
This tutorial demonstrates how a scientist designs and orders assay plates in Titian’s Mosaic, accepts and runs the fully automated screening process from within Cellario, and triggers the automated data analysis and approval in Genedata Screener. The overall workflow and its interfaces will be illustrated as well as the relevant interactions with the individual software components.
SLAS Author Workshop: How to Prepare a Manuscript for Publication Success
Thursday, 28 June | 13:15 – 14:30 | Studio 316
Join the editors-in-chief of the SLAS journals for a step-by-step overview of how to design and write scientific research papers more clearly and effectively to improve their chances for publication. Attendees will learn what editors want, what they don’t want, common mistakes, insider tips and how reviewers evaluate manuscripts. Presented by SLAS Discovery Editor-in-Chief Robert M. Campbell, Ph.D. (Eli Lilly & Co.) and SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D. (National University of Singapore). All participants are welcome to attend and encouraged to pick up a boxed lunch and soft drink from the Exhibition and bring it to the workshop.